H2N2V1, Main, Exploration, bibRecord, 002709

Analysis of genome composition and reactogenicity of recombinants of cold-adapted and virulent virus strains.

Identifieur interne : 002709 ( Main/Exploration ); précédent : 002708; suivant : 002710

Analysis of genome composition and reactogenicity of recombinants of cold-adapted and virulent virus strains.

Auteurs : Y Z Ghendon ; A I Klimov ; G I Alexandrova ; F I Polezhaev

Source :

The Journal of general virology [ 0022-1317 ] ; 1981.

RBID : pubmed:7264609

Descripteurs français

KwdFr :
- Adulte, Anticorps antiviraux (biosynthèse), Basse température, Gènes viraux, Humains, Mutation, Protéines virales (analyse), Recombinaison génétique, Vaccination, Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (pathogénicité).
MESH :
- analyse : Protéines virales.
- biosynthèse : Anticorps antiviraux.
- génétique : Virus de la grippe A.
- immunologie : Virus de la grippe A.
- pathogénicité : Virus de la grippe A.
- Adulte, Basse température, Gènes viraux, Humains, Mutation, Recombinaison génétique, Vaccination.

English descriptors

KwdEn :
- Adult, Antibodies, Viral (biosynthesis), Cold Temperature, Genes, Viral, Humans, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (pathogenicity), Mutation, Recombination, Genetic, Vaccination, Viral Proteins (analysis).
MESH :
- chemical , analysis : Viral Proteins.
- chemical , biosynthesis : Antibodies, Viral.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- pathogenicity : Influenza A virus.
- Adult, Cold Temperature, Genes, Viral, Humans, Mutation, Recombination, Genetic, Vaccination.

Abstract

Temperature-sensitive (ts) mutations occurring in three genes, 1, 2, and 7, and 1, 5 and 7 were found in two cold-adapted (ts) attenuated influenza virus strains A/Leningrad/9/37/46 (H0N1) and A/Leningrad/134/17/57 (H2N2) respectively. The recombinants, obtained by crossing these cold-adapted strains with virulent influenza virus strains, had different genome structures and inherited from one to six genes from the cold-adapted parents. Tests of reactogenicity of recombinants in volunteers showed all the recombinants to be non-reactogenic irrespective of the number of genes inherited from the cold-adapted parent.

DOI: 10.1099/0022-1317-53-2-215
PubMed: 7264609

Affiliations:

Le document en format XML

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<term>Humans</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (pathogenicity)</term>
<term>Mutation</term>
<term>Recombination, Genetic</term>
<term>Vaccination</term>
<term>Viral Proteins (analysis)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Anticorps antiviraux (biosynthèse)</term>
<term>Basse température</term>
<term>Gènes viraux</term>
<term>Humains</term>
<term>Mutation</term>
<term>Protéines virales (analyse)</term>
<term>Recombinaison génétique</term>
<term>Vaccination</term>
<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Virus de la grippe A (pathogénicité)</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Viral Proteins</term>
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</keywords>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term>
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<term>Basse température</term>
<term>Gènes viraux</term>
<term>Humains</term>
<term>Mutation</term>
<term>Recombinaison génétique</term>
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<front><div type="abstract" xml:lang="en">Temperature-sensitive (ts) mutations occurring in three genes, 1, 2, and 7, and 1, 5 and 7 were found in two cold-adapted (ts) attenuated influenza virus strains A/Leningrad/9/37/46 (H0N1) and A/Leningrad/134/17/57 (H2N2) respectively. The recombinants, obtained by crossing these cold-adapted strains with virulent influenza virus strains, had different genome structures and inherited from one to six genes from the cold-adapted parents. Tests of reactogenicity of recombinants in volunteers showed all the recombinants to be non-reactogenic irrespective of the number of genes inherited from the cold-adapted parent.</div>
</front>
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<name sortKey="Ghendon, Y Z" sort="Ghendon, Y Z" uniqKey="Ghendon Y" first="Y Z" last="Ghendon">Y Z Ghendon</name>
<name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name>
<name sortKey="Polezhaev, F I" sort="Polezhaev, F I" uniqKey="Polezhaev F" first="F I" last="Polezhaev">F I Polezhaev</name>
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Serveur d'exploration H2N2

Analysis of genome composition and reactogenicity of recombinants of cold-adapted and virulent virus strains.

Analysis of genome composition and reactogenicity of recombinants of cold-adapted and virulent virus strains.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
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